Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC2758934 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Zhou Zheng Z Zhen Juan J Karpowich Nathan K NK Law Christopher J CJ Reith Maarten E A ME Wang Da-Neng DN
Nature structural & molecular biology 20090510 6
Sertraline and fluoxetine are selective serotonin re-uptake inhibitors (SSRIs) that are widely prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT). All SSRIs possess halogen atoms at specific positions, which are key determinants for the drugs' specificity for SERT. For the SERT protein, however, the structural basis of its specificity for SSRIs is poorly understood. Here we report the crystal structures of LeuT, a b ...[more]