Ontology highlight
ABSTRACT:
SUBMITTER: Turner CE
PROVIDER: S-EPMC2759039 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Turner Claire E CE Kurupati Prathiba P Wiles Siouxsie S Edwards Robert J RJ Sriskandan Shiranee S
Vaccine 20090627 36
Currently there is no licensed vaccine against the human pathogen Streptococcus pyogenes. The highly conserved IL-8 cleaving S. pyogenes cell envelope proteinase SpyCEP is surface expressed and is a potential vaccine candidate. A recombinant N-terminal part of SpyCEP (CEP) was expressed and purified. AntiCEP antibodies were found to neutralize the IL-8 cleaving activity of SpyCEP. CEP-immunized mice had reduced bacterial dissemination from focal S. pyogenes intramuscular infection and intranasal ...[more]