Ontology highlight
ABSTRACT:
SUBMITTER: Tategu M
PROVIDER: S-EPMC2759144 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Tategu Moe M Arauchi Takako T Tanaka Rena R Nakagawa Hiroki H Yoshida Kenichi K
Gene regulation and systems biology 20070501
Fanconi anemia (FA) is an autosomal recessive disorder characterized by congenital abnormalities, bone marrow failure, chromosome fragility, and cancer susceptibility. At least eleven members of the FA gene family have been identified using complementation experiments. Ubiquitin-proteasome has been shown to be a key regulator of FA proteins and their involvement in the repair of DNA damage. Here, we identified a novel functional link between the FA/BRCA pathway and E2F-mediated cell cycle regulo ...[more]