Ontology highlight
ABSTRACT:
SUBMITTER: Zid BM
PROVIDER: S-EPMC2759400 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Zid Brian M BM Rogers Aric N AN Katewa Subhash D SD Vargas Misha A MA Kolipinski Marysia C MC Lu Tony Au TA Benzer Seymour S Kapahi Pankaj P
Cell 20091001 1
Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila. A number of nuclear encoded mitochondrial genes, including those in Complex I and IV of the electron transport chain, showed increased ribosomal loading and enhanced overall activity upon DR. We found that various mitochondrial genes possessed shorter and less structured 5'UTRs, which were important for their enhanced ...[more]