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GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data.

ABSTRACT: The current fast growth of genome-wide association studies (GWAS) combined with now common computationally expensive imputation requires the online access of large user groups to high-performance computing resources capable of analyzing rapidly and efficiently millions of genetic markers for ten thousands of individuals. Here, we present a web-based interface--called GRIMP--to run publicly available genetic software for extremely large GWAS on scalable super-computing grid infrastructures. This is of major importance for the enlargement of GWAS with the availability of whole-genome sequence data from the 1000 Genomes Project and for future whole-population efforts.

SUBMITTER: Estrada K

PROVIDER: S-EPMC2759548 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data.

Estrada Karol K Abuseiris Anis A Grosveld Frank G FG Uitterlinden André G AG Knoch Tobias A TA Rivadeneira Fernando F

Bioinformatics (Oxford, England) 20090821 20

The current fast growth of genome-wide association studies (GWAS) combined with now common computationally expensive imputation requires the online access of large user groups to high-performance computing resources capable of analyzing rapidly and efficiently millions of genetic markers for ten thousands of individuals. Here, we present a web-based interface--called GRIMP--to run publicly available genetic software for extremely large GWAS on scalable super-computing grid infrastructures. This ...[more]

PMID: 19700477

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Project description:BackgroundMicroarray techniques are one of the main methods used to investigate thousands of gene expression profiles for enlightening complex biological processes responsible for serious diseases, with a great scientific impact and a wide application area. Several standalone applications had been developed in order to analyze microarray data. Two of the most known free analysis software packages are the R-based Bioconductor and dChip. The part of dChip software concerning the calculation and the analysis of gene expression has been modified to permit its execution on both cluster environments (supercomputers) and Grid infrastructures (distributed computing).This work is not aimed at replacing existing tools, but it provides researchers with a method to analyze large datasets without any hardware or software constraints.ResultsAn application able to perform the computation and the analysis of gene expression on large datasets has been developed using algorithms provided by dChip. Different tests have been carried out in order to validate the results and to compare the performances obtained on different infrastructures. Validation tests have been performed using a small dataset related to the comparison of HUVEC (Human Umbilical Vein Endothelial Cells) and Fibroblasts, derived from same donors, treated with IFN-alpha.Moreover performance tests have been executed just to compare performances on different environments using a large dataset including about 1000 samples related to Breast Cancer patients.ConclusionA Grid-enabled software application for the analysis of large Microarray datasets has been proposed. DChip software has been ported on Linux platform and modified, using appropriate parallelization strategies, to permit its execution on both cluster environments and Grid infrastructures. The added value provided by the use of Grid technologies is the possibility to exploit both computational and data Grid infrastructures to analyze large datasets of distributed data. The software has been validated and performances on cluster and Grid environments have been compared obtaining quite good scalability results.

Dataset Information

GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data.

Publications

GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data.

Similar Datasets

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