Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women.
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SUBMITTER: Ahmed T
PROVIDER: S-EPMC2759570 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women.
Ahmed Tanvir T Das Sai Krupa SK Golden Julie K JK Saltzman Edward E Roberts Susan B SB Meydani Simin Nikbin SN
The journals of gerontology. Series A, Biological sciences and medical sciences 20090728 11
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E(2) (PGE(2)) productions were determine ...[more]
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