Ontology highlight
ABSTRACT:
SUBMITTER: Venkatachari NJ
PROVIDER: S-EPMC2759578 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Venkatachari Narasimhan J NJ Alber Sean S Watkins Simon C SC Ayyavoo Velpandi V
PloS one 20091015 10
Dendritic cells (DC) play a pivotal role in transmission and dissemination of HIV-1. Earlier studies reported that DC present at the site of infection trap virus particles via DC-SIGN and transfer the virus to the interacting naïve T cells. This prompted us to ask the question whether DC could acquire virus from infected T cells during DC-T cell interaction. To address this, we investigated the likely transfer of virus from HIV-1 infected T cells to DC and the underlying mechanisms involved. Res ...[more]