Vesicular stomatitis virus inhibits mitotic progression and triggers cell death.
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ABSTRACT:
SUBMITTER: Chakraborty P
PROVIDER: S-EPMC2759734 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Vesicular stomatitis virus inhibits mitotic progression and triggers cell death.
Chakraborty Papia P Seemann Joachim J Mishra Ram K RK Wei Jen-Hsuan JH Weil Lauren L Nussenzveig Daniel R DR Heiber Joshua J Barber Glen N GN Dasso Mary M Fontoura Beatriz M A BM
EMBO reports 20090911 10
Vesicular stomatitis virus (VSV) infects and kills a wide range of cell types; however, the mechanisms involved in VSV-mediated cell death are not fully understood. Here we show that VSV infection interferes with mitotic progression, resulting in cell death. This effect requires the interaction of VSV matrix (M) protein with the Rae1-Nup98 complex in mitosis, which is associated with a subset of ribonucleoproteins (RNPs). VSV displaced Rae1 from spindle poles, caused spindle abnormalities and tr ...[more]
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Project description:Vesicular stomatitis virus (VSV): Genome sequencing and assembly
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