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Netting neutrophils in autoimmune small-vessel vasculitis.

ABSTRACT: Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

SUBMITTER: Kessenbrock K

PROVIDER: S-EPMC2760083 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Netting neutrophils in autoimmune small-vessel vasculitis.

Kessenbrock Kai K Krumbholz Markus M Schönermarck Ulf U Back Walter W Gross Wolfgang L WL Werb Zena Z Gröne Hermann-Josef HJ Brinkmann Volker V Jenne Dieter E DE

Nature medicine 20090601 6

Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response a ...[more]

PMID: 19448636

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