Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC2760350 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Zhu Yuan Y Harada Takayuki T Liu Li L Lush Mark E ME Guignard Frantz F Harada Chikako C Burns Dennis K DK Bajenaru M Livia ML Gutmann David H DH Parada Luis F LF
Development (Cambridge, England) 20051201 24
The gene responsible for neurofibromatosis type 1 (NF1) encodes a tumor suppressor that functions as a negative regulator of the Ras proto-oncogene. Individuals with germline mutations in NF1 are predisposed to the development of benign and malignant tumors of the peripheral and central nervous system (CNS). Children with this disease suffer a high incidence of optic gliomas, a benign but potentially debilitating tumor of the optic nerve; and an increased incidence of malignant astrocytoma, reac ...[more]