Ontology highlight
ABSTRACT:
SUBMITTER: Meulenbroek EM
PROVIDER: S-EPMC2760361 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Meulenbroek Elisabeth M EM Paspaleva Keti K Thomassen Ellen A J EA Abrahams Jan Pieter JP Goosen Nora N Pannu Navraj S NS
Protein science : a publication of the Protein Society 20090301 3
UV damage endonuclease is a DNA repair enzyme that can both recognize damage such as UV lesions and introduce a nick directly 5' to them. Recently, the crystal structure of the enzyme from Thermus thermophilus was solved. In the electron density map of this structure, unexplained density near the active site was observed at the tip of Lys229. Based on this finding, it was proposed that Lys229 is post-translationally modified. In this article, we give evidence that this modification is a carboxyl ...[more]