Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC2761030 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Liu Lin L Botos Istvan I Wang Yan Y Leonard Joshua N JN Shiloach Joseph J Segal David M DM Davies David R DR
Science (New York, N.Y.) 20080401 5874
Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECDs) dimerize on oligonucleotides of at least 40 to 50 base pairs in length, the minimal length required for signal transduction. To establish the molecular basis for ligand binding and signaling, we determined the crystal structure of a complex between two mouse TLR3-ECDs and dsRNA at 3.4 angstrom resolution. ...[more]