Ontology highlight
ABSTRACT:
SUBMITTER: Nozumi M
PROVIDER: S-EPMC2761339 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Nozumi Motohiro M Togano Tetsuya T Takahashi-Niki Kazuko K Lu Jia J Honda Atsuko A Taoka Masato M Shinkawa Takashi T Koga Hisashi H Takeuchi Kosei K Isobe Toshiaki T Igarashi Michihiro M
Proceedings of the National Academy of Sciences of the United States of America 20090928 40
Identification of proteins in the mammalian growth cone has the potential to advance our understanding of this critical regulator of neuronal growth and formation of neural circuit; however, to date, only one growth cone marker protein, GAP-43, has been reported. Here, we successfully used a proteomic approach to identify 945 proteins present in developing rat forebrain growth cones, including highly abundant, membrane-associated and actin-associated proteins. Almost 100 of the proteins appear t ...[more]