Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.
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ABSTRACT:
SUBMITTER: Simon-Sanchez J
PROVIDER: S-EPMC2761542 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
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Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.
Simón-Sánchez Javier J Seelaar Harro H Bochdanovits Zoltán Z Deeg Dorly J H DJ van Swieten John C JC Heutink Peter P
PloS one 20091022 10
<h4>Background</h4>A single nucleotide polymorphism (rs5848) located in the 3'- untranslated region of GRN has recently been associated with a risk of frontotemporal lobar degeneration (FTLD) in North American population particularly in pathologically confirmed cases with neural inclusions immunoreactive for ubiquitin and TAR DNA-binding protein 43 (TDP-43), but negative for tau and alpha-synuclein (FTLD-TDP).<h4>Methodology/principal findings</h4>In an effort to replicate these results in a dif ...[more]
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