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One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.


ABSTRACT: Symmetric and asymmetric xanthene dyes have been prepared by a convenient one-step procedure from aldehyde and diol or m-aminophenol precursors using concentrated phosphoric acid as a solvent. This protocol provides access to water-soluble dyes with large Stoke's shifts and far-red fluorescence emission. These compounds are envisioned as components of fluorescence-based sensors for a variety of imaging applications.

SUBMITTER: Hilderbrand SA 

PROVIDER: S-EPMC2761723 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature

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One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.

Hilderbrand Scott A SA   Weissleder Ralph R  

Tetrahedron letters 20070601 25


Symmetric and asymmetric xanthene dyes have been prepared by a convenient one-step procedure from aldehyde and diol or m-aminophenol precursors using concentrated phosphoric acid as a solvent. This protocol provides access to water-soluble dyes with large Stoke's shifts and far-red fluorescence emission. These compounds are envisioned as components of fluorescence-based sensors for a variety of imaging applications. ...[more]

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