Ontology highlight
ABSTRACT:
SUBMITTER: Huo Y
PROVIDER: S-EPMC2762112 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Trends in cardiovascular medicine 20090501 4
Leukocyte recruitment to the arterial vessel wall is the first step in the development of atherosclerotic lesions. Leukocyte homing in this event proceeds through a well-defined adhesion cascade, which includes tethering, rolling, adhesion, and transmigration. Selectins, including the P-, E-, and L-selectins, and their ligands mediate the initial tethering and rolling. Interactions between selectins and their ligands serve as a braking system to decelerate fast-flowing leukocytes from the centra ...[more]