Ontology highlight
ABSTRACT:
SUBMITTER: Insaidoo FK
PROVIDER: S-EPMC2762276 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Insaidoo Francis K FK Zajicek Jaroslav J Baker Brian M BM
Biochemistry 20091001 41
T-Cell receptor recognition of peptides bound by major histocompatibility complex (MHC) proteins initiates a cellular immune response. Dynamics of peptides within MHC binding grooves can influence TCR recognition, yet NMR studies which could address this rigorously have been hindered by the expense of isotopically labeled peptides and the large size of peptide-MHC complexes. Here we describe a methodology for characterizing peptide dynamics within MHC binding grooves via NMR, using a biosyntheti ...[more]