Ontology highlight
ABSTRACT:
SUBMITTER: Trevino LR
PROVIDER: S-EPMC2762391 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Treviño Lisa R LR Yang Wenjian W French Deborah D Hunger Stephen P SP Carroll William L WL Devidas Meenakshi M Willman Cheryl C Neale Geoffrey G Downing James J Raimondi Susana C SC Pui Ching-Hon CH Evans William E WE Relling Mary V MV
Nature genetics 20090816 9
Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 x 10(-5)) between pediatric acute lymphoblastic leukemia (ALL) cases (n = 317) and non-ALL controls (n = 17,958). Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9), OR = 1.62) but also distinguished B-hyperdiploid ALL from other subtypes (rs10821936 ...[more]