Ontology highlight
ABSTRACT:
SUBMITTER: Stocco G
PROVIDER: S-EPMC2762405 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Stocco G G Cheok M H MH Crews K R KR Dervieux T T French D D Pei D D Yang W W Cheng C C Pui C-H CH Relling M V MV Evans W E WE
Clinical pharmacology and therapeutics 20080806 2
The influence of genetic polymorphism in inosine triphosphate pyrophosphatase (ITPA) on thiopurine-induced adverse events has not been investigated in the context of combination chemotherapy for acute lymphoblastic leukemia (ALL). This study investigated the effects of a common ITPA variant allele (rs41320251) on mercaptopurine metabolism and toxicity during treatment of children with ALL. Significantly higher concentrations of methyl mercaptopurine nucleotides were found in patients with the no ...[more]