Ontology highlight
ABSTRACT:
SUBMITTER: Brown V
PROVIDER: S-EPMC2762736 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Brown Victoria V Brown Rachel A RA Ozinsky Adrian A Hesselberth Jay R JR Fields Stanley S
European journal of immunology 20060301 3
MyD88 participates in signal transduction by binding to the cytoplasmic Toll/IL-1 receptor (TIR) domains of activated Toll-like receptors (TLR). Yeast two-hybrid experiments reveal that the TIR domains of human TLR differ in their ability to associate with MyD88: The TIR of TLR2 binds to MyD88 but the TIR of the closely related TLR1, 6, or 10 do not. Using chimeric TIR domains, we define the critical region responsible for differential MyD88 binding, and use a computational analysis of the criti ...[more]