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A central role for induced regulatory T cells in tolerance induction in experimental colitis.

ABSTRACT: In addition to thymus-derived or natural T regulatory (nT(reg)) cells, a second subset of induced T regulatory (iT(reg)) cells arises de novo from conventional CD4(+) T cells in the periphery. The function of iT(reg) cells in tolerance was examined in a CD45RB(high)CD4(+) T cell transfer model of colitis. In situ-generated iT(reg) cells were similar to nT(reg) cells in their capacity to suppress T cell proliferation in vitro and their absence in vivo accelerated bowel disease. Treatment with nT(reg) cells resolved the colitis, but only when iT(reg) cells were also present. Although iT(reg) cells required Foxp3 for suppressive activity and phenotypic stability, their gene expression profile was distinct from the established nT(reg) "genetic signature," indicative of developmental and possibly mechanistic differences. These results identified a functional role for iT(reg) cells in vivo and demonstrated that both iT(reg) and nT(reg) cells can act in concert to maintain tolerance.

SUBMITTER: Haribhai D

PROVIDER: S-EPMC2763205 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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A central role for induced regulatory T cells in tolerance induction in experimental colitis.

Haribhai Dipica D Lin Wen W Edwards Brandon B Ziegelbauer Jennifer J Salzman Nita H NH Carlson Marc R MR Li Shun-Hwa SH Simpson Pippa M PM Chatila Talal A TA Williams Calvin B CB

Journal of immunology (Baltimore, Md. : 1950) 20090301 6

In addition to thymus-derived or natural T regulatory (nT(reg)) cells, a second subset of induced T regulatory (iT(reg)) cells arises de novo from conventional CD4(+) T cells in the periphery. The function of iT(reg) cells in tolerance was examined in a CD45RB(high)CD4(+) T cell transfer model of colitis. In situ-generated iT(reg) cells were similar to nT(reg) cells in their capacity to suppress T cell proliferation in vitro and their absence in vivo accelerated bowel disease. Treatment with nT( ...[more]

PMID: 19265124

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Dataset Information

A central role for induced regulatory T cells in tolerance induction in experimental colitis.

Publications

A central role for induced regulatory T cells in tolerance induction in experimental colitis.

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