Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140.

ABSTRACT:

Background

Mechanisms that underlie oscillatory transcriptional activity of nuclear receptors (NRs) are incompletely understood. Evidence exists for rapid, cyclic recruitment of coregulatory complexes upon activation of nuclear receptors. RIP140 is a NR coregulator that represses the transactivation of agonist-bound nuclear receptors. Previously, we showed that RIP140 is inducible by all-trans retinoic acid (RA) and mediates limiting, negative-feedback regulation of retinoid signaling.

Methodology and findings

Here we report that in the continued presence of RA, long-paced oscillations of retinoic acid receptor (RAR) activity occur with a period ranging from 24 to 35 hours. Endogenous expression of RIP140 and other RA-target genes also oscillate in the presence of RA. Cyclic

SUBMITTER: Heim KC 

PROVIDER: S-EPMC2763268 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature