Ontology highlight
ABSTRACT:
SUBMITTER: Mooney RA
PROVIDER: S-EPMC2763281 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Mooney Rachel Anne RA Schweimer Kristian K Rösch Paul P Gottesman Max M Landick Robert R
Journal of molecular biology 20090603 2
NusG is a conserved regulatory protein that interacts with elongation complexes (ECs) of RNA polymerase, DNA, and RNA to modulate transcription in multiple and sometimes opposite ways. In Escherichia coli, NusG suppresses pausing and increases elongation rate, enhances termination by E. coli rho and phage HK022 Nun protein, and promotes antitermination by lambdaN and in ribosomal RNA operons. We report NMR studies that suggest that E. coli NusG consists of two largely independent N- and C-termin ...[more]