Ontology highlight
ABSTRACT:
SUBMITTER: Nathans R
PROVIDER: S-EPMC2763548 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Nathans Robin R Chu Chia-Ying CY Serquina Anna Kristina AK Lu Chih-Chung CC Cao Hong H Rana Tariq M TM
Molecular cell 20090601 6
MicroRNAs (miRNAs), approximately 22 nt noncoding RNAs, assemble into RNA-induced silencing complexes (RISCs) and localize to cytoplasmic substructures called P bodies. Dictated by base-pair complementarity between miRNA and a target mRNA, miRNAs specifically repress posttranscriptional expression of several mRNAs. Here we report that HIV-1 mRNA interacts with RISC proteins and that disrupting P body structures enhances viral production and infectivity. In HIV-1-infected human T lymphocytes, we ...[more]