Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC2763553 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Liu Jing J Zhang Hongqi H Li Zhiqiang Z Hailemariam Tiruneh K TK Chakraborty Mahua M Jiang Kailiu K Qiu Daniel D Bui Hai H HH Peake David A DA Kuo Ming-Shang MS Wadgaonkar Raj R Cao Guoqing G Jiang Xian-Cheng XC
Arteriosclerosis, thrombosis, and vascular biology 20090312 6
<h4>Background</h4>It has been proposed that plasma sphingomyelin (SM) plays a very important role in plasma lipoprotein metabolism and atherosclerosis. Sphingomyelin synthase (SMS) is the last enzyme for SM de novo biosynthesis. Two SMS genes, SMS1 and SMS2, have been cloned and characterized.<h4>Methods and results</h4>To evaluate the in vivo role of SMS2 in SM metabolism, we prepared SMS2 knockout (KO) and SMS2 liver-specific transgenic (LTg) mice and studied their plasma SM and lipoprotein m ...[more]