Ontology highlight
ABSTRACT:
SUBMITTER: Daber R
PROVIDER: S-EPMC2763795 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Daber Robert R Lewis Mitchell M
Protein engineering, design & selection : PEDS 20090902 11
Transcriptional regulation is an essential component of all metabolic pathways. At the most basic level, a protein binds to a particular DNA sequence (operator) on the genome and either positively or negatively alters the level of transcription. Together, the protein and its operator form an epigenetic switch that regulates gene expression. In an effort to produce a 'better' switch, we have discovered novel facets of the lac operon that are responsible for optimal functionality. We have uncovere ...[more]