Ontology highlight
ABSTRACT:
SUBMITTER: Lim KW
PROVIDER: S-EPMC2764449 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Nucleic acids research 20090819 18
Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G.C base pair and a G.C.G.C tetrad ...[more]