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ABSTRACT:
SUBMITTER: Mashima T
PROVIDER: S-EPMC2764455 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Mashima Tsukasa T Matsugami Akimasa A Nishikawa Fumiko F Nishikawa Satoshi S Katahira Masato M
Nucleic acids research 20090807 18
RNA aptamers against bovine prion protein (bPrP) were obtained, most of the obtained aptamers being found to contain the r(GGAGGAGGAGGA) (R12) sequence. Then, it was revealed that R12 binds to both bPrP and its beta-isoform with high affinity. Here, we present the structure of R12. This is the first report on the structure of an RNA aptamer against prion protein. R12 forms an intramolecular parallel quadruplex. The quadruplex contains G:G:G:G tetrad and G(:A):G:G(:A):G hexad planes. Two quadrupl ...[more]