Ontology highlight
ABSTRACT:
SUBMITTER: Leone G
PROVIDER: S-EPMC2764862 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Leone Giuseppe G D'Alò Francesco F Zardo Giuseppe G Voso Maria Teresa MT Nervi Clara C
Current medicinal chemistry 20080101 13
Epigenetic mechanisms affecting chromatin structure contribute to regulate gene expression and assure the inheritance of information, which are essential for the proper expression of key regulatory genes in healthy cells, tissues and organs. In the medical field, an increasing body of evidence indicates that altered gene expression or de-regulated gene function lead to disease. Cancer cells also suffer a profound change in the genomic methylation patterns and chromatin status. Aberrant DNA methy ...[more]