Ontology highlight
ABSTRACT:
SUBMITTER: Nagy V
PROVIDER: S-EPMC2764879 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Nagy Vivien V Hsia Kuo-Chiang KC Debler Erik W EW Kampmann Martin M Davenport Andrew M AM Blobel Günter G Hoelz André A
Proceedings of the National Academy of Sciences of the United States of America 20091001 42
The heptameric Nup84 complex constitutes an evolutionarily conserved building block of the nuclear pore complex. Here, we present the crystal structure of the heterotrimeric Sec13 x Nup145C x Nup84 complex, the centerpiece of the heptamer, at 3.2-A resolution. Nup84 forms a U-shaped alpha-helical solenoid domain, topologically similar to two other members of the heptamer, Nup145C and Nup85. The interaction between Nup84 and Nup145C is mediated via a hydrophobic interface located in the kink regi ...[more]