Immunologically silent cancer clone transmission from mother to offspring.
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ABSTRACT:
SUBMITTER: Isoda T
PROVIDER: S-EPMC2764945 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
Immunologically silent cancer clone transmission from mother to offspring.
Isoda Takeshi T Ford Anthony M AM Tomizawa Daisuke D van Delft Frederik W FW De Castro David Gonzalez DG Mitsuiki Norkio N Score Joannah J Taki Tomohiko T Morio Tomohiro T Takagi Masatoshi M Saji Hiroh H Greaves Mel M Mizutani Shuki S
Proceedings of the National Academy of Sciences of the United States of America 20091012 42
Rare cases of possible materno-fetal transmission of cancer have been recorded over the past 100 years but evidence for a shared cancer clone has been very limited. We provide genetic evidence for mother to offspring transmission, in utero, of a leukemic cell clone. Maternal and infant cancer clones shared the same unique BCR-ABL1 genomic fusion sequence, indicating a shared, single-cell origin. Microsatellite markers in the infant cancer were all of maternal origin. Additionally, the infant, ma ...[more]
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2018-02-20 | GSE110888 | GEO