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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

ABSTRACT: We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.

SUBMITTER: Lutter M

PROVIDER: S-EPMC2765052 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Lutter Michael M Sakata Ichiro I Osborne-Lawrence Sherri S Rovinsky Sherry A SA Anderson Jason G JG Jung Saendy S Birnbaum Shari S Yanagisawa Masashi M Elmquist Joel K JK Nestler Eric J EJ Zigman Jeffrey M JM

Nature neuroscience 20080615 7

We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for gh ...[more]

PMID: 18552842

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