Ontology highlight
ABSTRACT:
SUBMITTER: Mutskov V
PROVIDER: S-EPMC2765094 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Mutskov Vesco V Felsenfeld Gary G
Proceedings of the National Academy of Sciences of the United States of America 20090928 41
Knowledge of how insulin (INS) gene expression is regulated will lead to better understanding of normal and abnormal pancreatic beta cell function. We have mapped histone modifications over the INS region, coupled with an expression profile, in freshly isolated islets from multiple human donors. Unlike many other human genes, in which active modifications tend to be concentrated within 1 kb around the transcription start site, these marks are distributed over the entire coding region of INS as w ...[more]