Ontology highlight
ABSTRACT:
SUBMITTER: Marmottant P
PROVIDER: S-EPMC2765233 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Marmottant Philippe P Mgharbel Abbas A Käfer Jos J Audren Benjamin B Rieu Jean-Paul JP Vial Jean-Claude JC van der Sanden Boudewijn B Marée Athanasius F M AF Graner François F Delanoë-Ayari Hélène H
Proceedings of the National Academy of Sciences of the United States of America 20090925 41
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If cell shape fluctuations are active enough, the aggregate spontaneously relaxes stresses ("fluctuation-induced flow"). If not, changing the aggregate's shape requires a sufficiently large applied stress ("stress-induced flow"). To capture this d ...[more]