Ontology highlight
ABSTRACT:
SUBMITTER: Castaldi PJ
PROVIDER: S-EPMC2765363 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Castaldi P J PJ DeMeo D L DL Kent D M DM Campbell E J EJ Barker A F AF Brantly M L ML Eden E E McElvaney N G NG Rennard S I SI Stocks J M JM Stoller J K JK Strange C C Turino G G Sandhaus R A RA Griffith J L JL Silverman E K EK
American journal of epidemiology 20090902 8
Alpha-1-antitrypsin deficiency is a genetic condition associated with severe, early-onset chronic obstructive pulmonary disease (COPD). However, there is significant variability in lung function impairment among persons with the protease inhibitor ZZ genotype. Early identification of persons at highest risk of developing lung disease could be beneficial in guiding monitoring and treatment decisions. Using a multicenter, family-based study sample (2002-2005) of 372 persons with the protease inhib ...[more]