Haplotype frequencies at the DRD2 locus in populations of the East European Plain.

ABSTRACT:

Background

It was demonstrated previously that the three-locus RFLP haplotype, TaqI B-TaqI D-TaqI A (B-D-A), at the DRD2 locus constitutes a powerful genetic marker and probably reflects the most ancient dispersal of anatomically modern humans.

Results

We investigated TaqI B, BclI, MboI, TaqI D, and TaqI A RFLPs in 17 contemporary populations of the East European Plain and Siberia. Most of these populations belong to the Indo-European or Uralic language families. We identified three common haplotypes, which occurred in more than 90% of chromosomes investigated. The frequencies of the haplotypes differed according to linguistic and geographical affiliation.

Conclusion

Populations in the northwestern (Byelorussians from Mjadel'), northern (Russians from Mezen' and Oshev

SUBMITTER: Flegontova OV 

PROVIDER: S-EPMC2765450 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature