Ontology highlight
ABSTRACT:
SUBMITTER: Chow KM
PROVIDER: S-EPMC2765508 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Chow K Martin KM Gakh O O Payne I C IC Juliano Maria Aparecida MA Juliano Luiz L Isaya G G Hersh Louis B LB
Biochemistry 20090401 13
The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified. The substrate specificity of MP1 was examined with physiological peptides as substrates. Although the enzyme exhibits broad substrate specificity, there is a trend for peptides containing 13 or more residues to exhibit K(m) values of 2 muM or less. Three of four peptides containing 11 or fewer residues exhibited K(m) values above 10 muM. Similarly ...[more]