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NGF is essential for hippocampal plasticity and learning.

ABSTRACT: Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (LTP), and learning were examined. NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal LTP. Blockade of endogenous NGF significantly reduced hippocampal LTP and impaired retention of spatial memory. These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain.

SUBMITTER: Conner JM

PROVIDER: S-EPMC2765804 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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NGF is essential for hippocampal plasticity and learning.

Conner James M JM Franks Kevin M KM Titterness Andrea K AK Russell Kyle K Merrill David A DA Christie Brian R BR Sejnowski Terrence J TJ Tuszynski Mark H MH

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090901 35

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (LTP), and learning were examined. NGF augment ...[more]

PMID: 19726646

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