Ontology highlight
ABSTRACT:
SUBMITTER: Peixoto PM
PROVIDER: S-EPMC2765813 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Peixoto Pablo M PM Ryu Shin-Young SY Pruzansky Dawn Pietkiewicz DP Kuriakose Maria M Gilmore Andrew A Kinnally Kathleen W KW
Biochemical and biophysical research communications 20090918 1
The death of one cell can precipitate the death of nearby cells in a process referred to as the bystander effect. We investigated whether mitochondrial apoptosis generated a bystander effect and, if so, by which pathway. Microinjection with cytochrome c mimicked function of the mitochondrial apoptosis-induced channel MAC and caused apoptosis of both target and nearby osteoblasts. This effect was suppressed by inhibiting gap junction intercellular communication. A bystander effect was also observ ...[more]