Informatics approaches to understanding TGFbeta pathway regulation.
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ABSTRACT:
SUBMITTER: Kahlem P
PROVIDER: S-EPMC2766340 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Informatics approaches to understanding TGFbeta pathway regulation.
Kahlem Pascal P Newfeld Stuart J SJ
Development (Cambridge, England) 20091101 22
In recent years, informatics studies have predicted several new ways in which the transforming growth factor beta (TGFbeta) signaling pathway can be post-translationally regulated. Subsequently, many of these predictions were experimentally validated. These approaches include phylogenetic predictions for the phosphorylation, sumoylation and ubiquitylation of pathway components, as well as kinetic models of endocytosis, phosphorylation and nucleo-cytoplasmic shuttling. We review these studies and ...[more]
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