Ontology highlight
ABSTRACT:
SUBMITTER: Popova AM
PROVIDER: S-EPMC2766618 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Popova Anna M AM Kálai Tamás T Hideg Kálmán K Qin Peter Z PZ
Biochemistry 20090901 36
In site-directed spin labeling, a covalently attached nitroxide probe containing a chemically inert unpaired electron is utilized to obtain information on the local environment of the parent macromolecule. Studies presented here examine the feasibility of probing local DNA structural and dynamic features using a class of nitroxide probes that are linked to chemically substituted phosphorothioate positions at the DNA backbone. Two members of this family, designated as R5 and R5a, were attached to ...[more]