Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC2766794 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Liu Gang G Zheng Hai H Ai Walden W
FEBS letters 20090912 19
We aimed to examine the physical interaction between CtBPs and KLF4 and the potential importance of this interaction. Co-immunoprecipitation indicated that CtBP1 indeed interacted with KLF4. This was supported by the co-localization of both KLF4 and CtBP1 in the promoter regions of KLF4 downstream target genes. In addition, overexpression of CtBP1 significantly decreased KLF4-mediated transcriptional activation in both an artificial (pGL5) and genuine (IAP and Keratin-4) reporter system. Mutatio ...[more]