Ontology highlight
ABSTRACT:
SUBMITTER: Kim JS
PROVIDER: S-EPMC2766844 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Kim Jong-So JS Coon Steven L SL Weller Joan L JL Blackshaw Seth S Rath Martin F MF Møller Morten M Klein David C DC
Journal of neurochemistry 20090519 2
Muscleblind-like 2 (Mbnl2) is a zinc finger protein first identified in Drosophila. It appears to be essential for photoreceptor development and to be involved in RNA splicing. Here we report that Mbnl2 is strongly expressed in the rat pineal gland. The abundance of pineal Mbnl2 transcripts follows a marked circadian rhythm with peak levels approximately sevenfold higher at night than day levels. Mbnl2 protein exhibits a similar rhythm. In vitro studies indicate that the abundance of Mbnl2 trans ...[more]