Ontology highlight
ABSTRACT:
SUBMITTER: Backer JM
PROVIDER: S-EPMC2767218 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Backer Joseph M JM Krivoshein Arcadius V AV Hamby Carl V CV Pizzonia John J Gilbert Kenneth S KS Ray Yonaton S YS Brand Harrison H Paton Adrienne W AW Paton James C JC Backer Marina V MV
Neoplasia (New York, N.Y.) 20091101 11
Diverse physiological and therapeutic insults that increase the amount of unfolded or misfolded proteins in the endoplasmic reticulum (ER) induce the unfolded protein response, an evolutionarily conserved protective mechanism that manages ER stress. Glucose-regulated protein 78/immunoglobulin heavy-chain binding protein (GRP78/BiP) is an ER-resident protein that plays a central role in the ER stress response and is the only known substrate of the proteolytic A subunit (SubA) of a novel bacterial ...[more]