Ontology highlight
ABSTRACT:
SUBMITTER: Trowbridge JJ
PROVIDER: S-EPMC2767228 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Trowbridge Jennifer J JJ Snow Jonathan W JW Kim Jonghwan J Orkin Stuart H SH
Cell stem cell 20091001 4
DNA methylation is essential for development and in diverse biological processes. The DNA methyltransferase Dnmt1 maintains parental cell methylation patterns on daughter DNA strands in mitotic cells; however, the precise role of Dnmt1 in regulation of quiescent adult stem cells is not known. To examine the role of Dnmt1 in adult hematopoietic stem cells (HSCs), we conditionally disrupted Dnmt1 in the hematopoietic system. Defects were observed in Dnmt1-deficient HSC self-renewal, niche retentio ...[more]