Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinoma.

ABSTRACT:

Background

No circulating markers are routinely used for renal cancer. The objective of this pilot study was to investigate whether conditioned media (CM) from renal cancer cell lines contains potential biomarkers that, when measured in clinical fluids, have diagnostic or prognostic utility.

Methods

Comparative 2D PAGE profiling of CM from renal cell carcinoma (RCC) and normal renal cultures identified cathepsin D that was subsequently validated in urine samples from 239 patients and healthy and benign disease subjects.

Results

Urinary cathepsin D was found to be significantly associated with overall (OS) (hazard ratio, HR, 1.33, 95%CI [1.09-1.63], P=0.005) and cancer-specific survival (HR 1.36, 95%CI [1.07-1.74], P=0.013) in RCC patients on univariate analysis. An op

SUBMITTER: Vasudev NS 

PROVIDER: S-EPMC2768081 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature