Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC2768414 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Chen Ding D Chai Jijie J Hart P John PJ Zhong Guangming G
Archives of biochemistry and biophysics 20090501 1
A secreted chlamydial protease designated CPAF (Chlamydial Protease/proteasome-like Activity Factor) degrades host proteins, enabling Chlamydia to evade host defenses and replicate. The mechanistic details of CPAF action, however, remain obscure. We used a computational approach to search the protein databank for structures that are compatible with the CPAF amino acid sequence. The results reveal that CPAF possesses a fold similar to that of the catalytic domains of the tricorn protease from The ...[more]