Ontology highlight
ABSTRACT:
SUBMITTER: Farmer WT
PROVIDER: S-EPMC2768610 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Farmer W Todd WT Altick Amy L AL Nural Hikmet Feyza HF Dugan James P JP Kidd Thomas T Charron Frédéric F Mastick Grant S GS
Development (Cambridge, England) 20081008 22
Longitudinal axons transmit all signals between the brain and spinal cord. Their axon tracts through the brain stem are established by a simple set of pioneer axons with precise trajectories parallel to the floor plate. To identify longitudinal guidance mechanisms in vivo, the overall role of floor plate tissue and the specific roles of Slit/Robo signals were tested. Ectopic induction or genetic deletion of the floor plate diverted longitudinal axons into abnormal trajectories. The expression pa ...[more]