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Genetic and genomic insights into age at natural menopause.


ABSTRACT: The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause could also play a role in those diseases, as well as infertility in women. In this minireview we comment on the latest genetics and genomics insights into age at natural menopause.

SUBMITTER: Moron FJ 

PROVIDER: S-EPMC2768962 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Genetic and genomic insights into age at natural menopause.

Moron Francisco Jesus FJ   Ruiz Agustin A   Galan Jose Jorge JJ  

Genome medicine 20090806 8


The age at natural menopause shows great variability. It has been proposed that early age at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later age at menopause is a risk factor for breast cancer. In addition, it is thought that the genetic factors accounting for the genetic variability in age at menopause could also play a role in those diseases, as well as infertility in women. In this minireview we comment on the latest genetics and genomics insights into ag  ...[more]

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