Ontology highlight
ABSTRACT:
SUBMITTER: Barry EL
PROVIDER: S-EPMC2769932 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Barry Elizabeth L EL Sansbury Leah B LB Grau Maria V MV Ali Iqbal U IU Tsang Shirley S Munroe David J DJ Ahnen Dennis J DJ Sandler Robert S RS Saibil Fred F Gui Jiang J Bresalier Robert S RS McKeown-Eyssen Gail E GE Burke Carol C Baron John A JA
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090915 10
Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the production of prostaglandins, potent mediators of inflammation. Chronic inflammation plays an important role in the development and progression of colorectal cancer. Aspirin inhibits COX-2 activity and lowers the risk for colorectal adenomas and cancer. We investigated whether common genetic variation in COX-2 influenced risk for colorectal adenoma recurrence among 979 participants in the Aspirin/Folate Polyp Prevention Study who w ...[more]